When first arriving in a new city, it is important to get to know your new surroundings. I would suggest buying a MUNI bus pass for about $60. You wont know your favorite San Francisco spots until you take one of the San Francisco City Tours. The tour will show you around the city as well stop at a lot of the more famous attractions.
After you have explored the city, try taking your trip to the surrounding areas that California has to offer. A beautiful wine country awaits you on the Muir Woods and Wine Country Tour.
Extranomical will really show you a wonderful San Francisco experience. Smaller groups, educated guides, complimentary wine tasting and hotel pick up, make Extranomical stand out among its competition.